THE THYROID CYTOTOXIC AUTOANTIBODY

Natural cytotoxic autoantibody against thymocytes in spontaneously hypertensive rats.

A strain of SHR, which spontaneously develops hypertension and cardiovascular diseases, had a decreasing number of rosette forming T-cells in their thymuses and a progressive decline in cellular immune functions such as blastogenic responses to PHA, delayed type hypersensitivity and allograft rejections by aging (Takeichi et al., Clin. exp. Immunol., 40: 120, 1980). A cell cooperation experimen...

Autoantibody profile in thyroid diseases in black Kenyans.

A controlled prospective study of autoantibody profile on black Kenyan patients with non-toxic goitre (116), thyrotoxicosis (131) and age, sex matched hospital controls is reported. The prevalence of thyroid microsomal and thyroglobulin antibodies is 3.5% in smooth non-toxic goitre and is 5.2% in the nodular non-toxic goitre compared to 1% of the control. The results reflect that autoimmune thy...

Studies on the Cytotoxic Factor in Thyroid Disease.

The presence of cytotoxic autoantibody to lacrimal gland cells in NZB/W mice.

New Zealand Black and White F1 hybrid mice (NZB/W mice) spontaneously develop an autoimmune disease which provides us with a suitable animal model for Sjögren's syndrome. With increasing age, these mice develop foci of mononuclear cell infiltration in the lacrimal and salivary glands, which closely resemble the lesions seen in patients with Sjögren's syndrome. We studied the cell-mediated and a...

Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody.

OBJECTIVE To analyze interactions between the thyroid-stimulating hormone receptor (TSHR) and a thyroid-stimulating human monoclonal autoantibody (M22) at the molecular level. DESIGN A complex of part of the TSHR extracellular domain (amino acids 1-260; TSHR260) bound to M22 Fab was prepared and purified. Crystals suitable for X-ray diffraction analysis were obtained and the structure solved ...